이선구 사진
이선구
직위(직급)
교수
전화번호
051-510-2786
이메일
sungulee@pusan.ac.kr
사이트
연구분야
생물분자설계
 주요 학력


학사 서울대학교 공업화학과(1994)

석사 서울대학교 공업화학과(1996)

박사 서울대학교 공업화학과(2001)

 주요 경력


2001-2003. 박사후연구원, Univerisity of California, LA
2003-2007. 조교수, 부산대학교
2007-2012. 부교수, 부산대학교

2012-현재.  교수, 부산대학교

 주요 학술지논문

1.    Redesigning of anti-c-Met single chain Fv antibody for the cytoplamic folding and its

      structural analysis. Selvakumar Edwardraja, Rameshkumar Neelamegam, Vijayaraj Ramadoss, Subramanian Venkatesan, Sun-Gu Lee . Biotechnology and Bioengineering, 106: 367-375 (2010)

 

2.    Engineering protein sequence composition for folding robustness renders efficient noncanonical amino acid incorporations. Nagasundarapandian S, Merkel L, Budisa N, Govindan R, Ayyadurai N, Sriram S, Yun H, Lee SG . ChemBioChem, 11: 2521-2524 (2010)

 

3.   Enhancing the thermal stability of a single-chain Fv fragment by in vivo global fluorination of the proline residues. Edwardraja S, Sriram S, Govindan R, Budisa N, Lee SG . Molecular Biosystems, 7:258-265. (2011 )

 

4.   A study on the effect of surface lysine to arginine mutagenesis on protein stability and structure using green fluorescent protein. Sokalingam S, Raghunathan G, Soundrarajan N, Lee SG . PLoS One . 7(7):e40410. (2012 )

 

5.   Conjugation of Proteins by Installing BIO-Orthogonally Reactive Groups at Their N-Termini. Soundrarajan N, Sokalingam S, Raghunathan G, Budisa N, Paik HJ, Yoo TH, Lee SG . PLoS One . 7(10):e46741 (2012 )

 

6.   Deletional protein engineering based on stable fold. Raghunathan G, Soundrarajan N, Sokalingam S, Yun H, Lee SG . PLoS One . 7(12):e51510. (2012 )

 

7.  Generation of Anti-c-Met Single Domain Antibody Fragment Based on Human Stable Frameworks. Selvakumar Edwardraja, Sriram Sokalingam, Govindan Raghunathan, Bum-Yeol Hwang, and Sun-Gu Lee . Biotechnology and Bioprocess Engineering 17: 1120-1127 (2012 )

 

8.   In silico Study on the Effect of Surface Lysines and Arginines on the Electrostatic Interactions and Protein Stability. Sriram Sokalingam , Bharat Madan , Govindan Raghunathan, and Sun-Gu Lee. Biotechnology and Bioprocess Engineering, 18(1):18-26 ( 2013)

 

9.  A Comparative Study on the Stability and Structure of Two Different Green Fluorescent Proteins in Organic Co-solvent Systems. Govindan Raghunathan, Sriram Sokalingam, Nagasundarapandian Soundrarajan, Ganapathiraman Munussami, Bharat Madan, and Sun-Gu Lee . Biotechnology and Bioprocess Engineering, 18: 342-349 (2013 )

 

10. Modulation of protein stability and aggregation property by surface charge engineering. Govindan Raghunathan, Sriram Sokalingam, Nagasundarapandian Soundrarajan, Bharat Madan, Ganapathiraman Munussami and Sun-Gu Lee . Molecular Biosystems , 9 (9): 2379 ? 2389 (2013 )

 

11.   Deciphering the Factors Responsible for the Stability of a GFP Variant Resistant to Alkaline pH Using Molecular Dynamics Simulations. Sriram Sokalingam , Bharat Madan , Govindan Raghunathan , and Sun-Gu Lee . Biotechnology and Bioprocess Engineering. 18(5):858-867 (2013 )

 

12.   A variant of green fluorescent protein exclusively deposited to active intracellular inclusion bodies. Govindan Raghunathan, Ganapathiraman Munussami, Hyojin Moon, Hyun-jong Paik, Seong Soo A An, Yong-Sung Kim, Sebyung Kang and Sun-Gu Lee . Microbial Cell Factories. 13: 68 (2014)

 

13. Modulation of Intracellular Protein Activity at Level of Protein Folding by Beta-turn Engineering. Bharat Madan and Sun-Gu Lee . Biotechnology and Bioprocess Engineering. 19: 433-441 (2014 )

 

14. Identification of an ideal-like fingerprint for a Protein Fold using Overlapped Conserved Residues based Approach. Amit Goyal, Sriram Sokalingam, Kyu-Suk Hwang and Sun-Gu Lee . Scientific Reports. 4: 5643 (2014 )

 

15.  Structural and sequence features of two residue turns in beta-hairpins . Bharat Madan, Sung Yong Seo, and Sun-Gu Lee. Proteins:structure, function and bioinformatics, 82(8), 1721?1733 (2014 )

 

16.   Redesigning the type II' β -turn in green fluorescent protein to type I': Implications for folding kinetics and stability. Bharat Madan, Sriram Sokalingam, Govindan Raghunathan and Sun-Gu Lee. Proteins:structure, function and bioinformatics, 82(10), 2812?2822 (2014 )

 

17. Identification of Novel Cupredoxin Homologs Using Overlapped Conserved Residues Based Approach. Amit Goyal, Bharat Madan, Kyu-Suk Hwang and Sun-Gu Lee. J. Microbiol. Biotechnol. 25(1), 127 ? 136 (2015 )

 

18. Identification of novel cytochrome P450 homologs using overlapped conserved residues based approach. Amit Goyal, Byung-Gee Kim, Kyu-Suk Hwang, Sun-Gu Lee. Biotechnology and Bioprocess Engineering, 20 (3), 431-438 ( 2015)

 

19. Engineering a beta-turn in green fluorescent protein to a foreign loop. Bharat Madan, Jayaraman Thangappan, Sun-Gu Lee , Journal of Industrial and Engineering Chemistry, 33, 330?335 (2016)

 

  주요 특허 및 기타 실적